Sialylation alterations of acute-phase proteins in mice with tumors

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Increased sialylation and defucosylation of plasma proteins are early events in the acute phase response.

Within hours of turpentine injection to stimulate the acute phase (AP) response in rats, the N-acetylneuraminic acid content of plasma proteins increases and that of fucose decreases, each by about 60%. The two changes are inversely related (r = -0.97). The NeuAc/Gal ratio increases from the normal 0.75 to 1.0 on day 2 of the AP. Whereas 50% of the isolated oligosaccharides of normal plasma pro...

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acute phase proteins efficacy in differential diagnosis

introduction: evaluating patient with acute scrotum is based on medical history (e.g. age), physical examination, blood tests, urine analysis and imaging studies. differential diagnosis may be difficult. efficacy of serum acute phase proteins in patients with acute scrotum was assessed in this study. materials and methods : 45 patients were recruited and allocated within three sub-groups; acute...

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Antioxidant Enzymes and Acute Phase Proteins Correlate with Marker of Lipid Peroxide in Adult Nigerian Sickle Cell Disease Patients

Objective(s) Sickle cell disease is a genetic disorder characterized by chronic haemolytic anaemia. Haemoglobin S containing red blood cells may be susceptible to oxidative stress due to imbalance between production of reactive oxygen species and the countering effect of the various antioxidants present in the body. Materials and Methods We evaluated some antioxidant enzymes which include gl...

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Protective Effects of Morin Hydrate on Acute Stress-Induced Behavioral and Biochemical Alterations in Mice

Introduction: As stress affects the brain both physiologically and chemically, researchers try to find novel anti-stress compounds with beneficial therapeutic effects. In this regard, the effect of stress and its modulation by Morin hydrate was studied using different acute models in mice. Methods: The models employed were anoxic tolerance, swimming endurance, and acute restraint test. Morin h...

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ژورنال

عنوان ژورنال: Journal of Proteome Research

سال: 2008

ISSN: 1535-3893,1535-3907

DOI: 10.1021/pr800446h